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Home - Products - GPCR/G Protein - Chemokine Receptor - RS-102895 hydrochloride

RS-102895 hydrochloride

CAS No. 1173022-16-6

RS-102895 hydrochloride( RS102895 hydrochloride )

Catalog No. M10577 CAS No. 1173022-16-6

A potent and specific CCR2 antagonist with binding IC50 of 360 nM; shows no significant affinity on CXCR1, CCR1, or CCR3.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    RS-102895 hydrochloride
  • Note
    Research use only, not for human use.
  • Brief Description
    A potent and specific CCR2 antagonist with binding IC50 of 360 nM; shows no significant affinity on CXCR1, CCR1, or CCR3.
  • Description
    A potent and specific CCR2 antagonist with binding IC50 of 360 nM; shows no significant affinity on CXCR1, CCR1, or CCR3. (IC50>17 uM); inhibits MCP-1-stimulated calcium influx into CCR2-CHL cells with IC50 of 32 nM; significantly attenuates HG-induced ECM protein expression and TGF-beta1 levels in mouse mesangial cells (MCs).
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    RS102895 hydrochloride
  • Pathway
    GPCR/G Protein
  • Target
    Chemokine Receptor
  • Recptor
    Chemokine Receptor
  • Research Area
    Inflammation/Immunology
  • Indication
    ——

Chemical Information

  • CAS Number
    1173022-16-6
  • Formula Weight
    426.8598
  • Molecular Formula
    C21H22ClF3N2O2
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO: ≥ 28 mg/mL
  • SMILES
    O=C1NC2=CC=CC=C2C3(CCN(CCC4=CC=C(C(F)(F)F)C=C4)CC3)O1.Cl
  • Chemical Name
    Spiro[4H-3,1-benzoxazine-4,4'-piperidin]-2(1H)-one, 1'-[2-[4-(trifluoromethyl)phenyl]ethyl]-, hydrochloride (1:1)

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Mirzadegan T, et al. J Biol Chem. 2000 Aug 18;275(33):25562-71. 2. Park J, et al. Am J Physiol Renal Physiol. 2008 Sep;295(3):F749-57. 3. Hung YW, et al. J Neuroinflammation. 2013 Jan 22;10:11.
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